Tag Archives: New Scientist

My Amazing Powers of Predicting Disaster: Failure of the Takahashi Trials

!!!!!!
Ahem.

Well, the Japanese Takahashi trials with the induced pluripotent stem cells are turning out to be a dangerous failure. Read all about it here. Just as SOMEBODY predicted. Hmm… I can’t imagine who…

Anyway. The trials were stopped because, in the words of New Scientist: “ genetic mutations were discovered in the cells of the second trial participant. One of the mutations may carry a remote risk of cancer.” (Remote… oh really? This is the same publication that has carried gushing fan news about the IPSC trials since Day One. Of course, so have all the rest… but still, I wouldn’t trust a disclaimer like that as far as I could throw it.)

Hmm… .WHO predicted this failure last year? WHO posted these predictions multiple times all over the web, including Paul Knoepfler’s blog and investorstemcell.com? WHO said it was way too soon to rush into the clinical setting when there hadn’t been even a tenth of the number of animal studies that should have happened first? WHO held fast to this prediction, even when nobody agreed with her and nobody wanted to hear about it?

Could it be… ME??

Hint: the answer is yes.

I’m NOT posting the link to Randy Travis singing “I Told You So” again. This is actually beyond even what I dared to predict last fall for the IPSC trials. That’s it. There HAS to be a way to turn this amazing psychic power to predict disaster into something valuable… (hmmm)

Anise: (poring over a crystal ball while clients wait impatiently) I can tell you all the Powerball combinations that aren’t going to win.

Clients: Isn’t there a faster way?

Anise: No. But I can give you all 174 million losing number combinations, and you just have to go through them– wait– where are you going??

The point is that I knew the IPSC trials wouldn’t work. They were rushed to the clinic crazy fast because it was a chance for Japan and Riken to get the first clinical trial of IPSC’s underway. This represented a chance to save face after the STAP cell disaster last year. To tell you the truth, it’s not rocket science and is very easy to piece together. However, this kind of outcome is what I hoped wouldn’t happen. But it was always a possibility. I posted long, long threads about it in the past, and we really don’t need to go into all of it again here… suffice it to say that there are good reasons to have a lot more animal trials before jumping immediately and dangerously fast into clinical trials.

You know… this sounds horrible, but the failure of these trials will ultimately help Ocata a lot. One by one, the inferior and not-ready-for-prime time stem cell treatments are falling. Ocata’s treatment for AMD is the only one that continues to advance through all trials with flying colors. And since this is treatment I would need… well, I think I have the cred to say it!!

Also, it would have been good for that article to get Ocata’s name right. 😛 But you know… there’s good and bad in everything.

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